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Main Dishes • Creamy Spicy Cajun Garlic Butter Chicken Penne

Creamy Spicy Cajun Garlic Butter Chicken Penne

September 28, 2025 by Debra

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Why Creamy Spicy Cajun Garlic Butter Chicken Penne is a Favorite

A bite of comfort with a Cajun twist

Hi! I’m Sofia Russo, a 42-year-old American living in the scenic Tuscan hills. My culinary journey began under the sun-drenched skies of a quaint Italian terrace. I can still recall that moment when one bite of sumptuous pasta changed my perspective on food forever.

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That love for Italian simplicity now marries beautifully with my affection for bold Cajun flavors in this Creamy Spicy Cajun Garlic Butter Chicken Penne recipe. Each forkful of pasta brings back echoes of those rustic Italian dinners, yet blended with a kick that’s simply irresistible.

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How this dish combines Italian tradition with Southern flair

Bringing together the creamy richness of garlic butter with the punchy notes of Cajun seasoning, this dish is a true celebration of cultures. The juxtaposition of the buttery sauce against the seasoned chicken and perfectly cooked penne creates a symphony of flavors.

It’s not just a meal; it’s a reminder of my time in Italy and the depth of learning I embraced through picking olives, preparing ricotta, and reveling in the wisdom of nonnas. You’ll find yourself enchanted by the balance of heat and comfort, making Creamy Spicy Cajun Garlic Butter Chicken Penne a dish worth adding to your repertoire.

How to Make Creamy Spicy Cajun Garlic Butter Chicken Penne

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Ingredients you’ll need

  • 1 lb chicken breast, diced
  • 12 oz penne pasta
  • 1/2 cup unsalted butter
  • 4 cloves garlic, minced
  • 1 cup heavy cream
  • 1 cup chicken broth
  • 2-3 tbsp Cajun seasoning (adjust to taste)
  • Salt and pepper to taste
  • 1 cup grated Parmesan cheese
  • 1/4 cup chopped parsley (for garnish)

Step-by-step instructions

  1. Cook the penne pasta according to package instructions until al dente. Drain and set aside.
  2. In a large skillet, melt the butter over medium heat. Add the minced garlic and sauté for 1-2 minutes until fragrant.
  3. Add the diced chicken to the skillet, seasoning with Cajun seasoning, salt, and pepper. Cook until browned and cooked through, about 6-8 minutes.
  4. Pour in the chicken broth and heavy cream, stirring to combine. Bring to a simmer and cook for 3-5 minutes until slightly thickened.
  5. Stir in the cooked penne and Parmesan cheese until the pasta is well coated and cheese is melted.
  6. Garnish with chopped parsley before serving.

Serving Creamy Spicy Cajun Garlic Butter Chicken Penne with Flair

What to serve with this Cajun-inspired pasta

When it comes to pairing Creamy Spicy Cajun Garlic Butter Chicken Penne, think about contrasts. A crisp side salad will lighten up the rich flavors and provide a refreshing bite. Toss together mixed greens, cherry tomatoes, cucumbers, and a simple vinaigrette to balance the creamy intensity of the dish.

Garlic bread or warm focaccia is a fantastic way to soak up any leftover sauce and complements the buttery goodness perfectly. If you enjoy a drink, consider serving a chilled white wine, such as Sauvignon Blanc or Chardonnay, which harmonizes beautifully with the creaminess of the sauce. Alternatively, an iced tea can offer a delightful Southern touch to your meal.

Delicious variations worth trying

Don’t hesitate to get creative with your Creamy Spicy Cajun Garlic Butter Chicken Penne! For a delightful seafood twist, try adding shrimp in place of chicken; it pairs wonderfully with the Cajun spices and creamy sauce.

If you’re looking for a lighter option, swapping out the chicken for turkey sausage not only lowers the calories but also adds a new layer of flavor. For those who crave extra spice, consider a dash of hot sauce or a sprinkle of crushed red pepper to kick up the heat.

Veggie lovers can enhance the dish by tossing in sautéed bell peppers, spinach, or even mushrooms for added nutrition and flavor. This versatility makes the Creamy Spicy Cajun Garlic Butter Chicken Penne suitable for any palate, ensuring there’s always a delicious option to enjoy!

How to Store and Reheat Cajun Garlic Butter Chicken Penne

Best way to store and keep flavor

To keep your Creamy Spicy Cajun Garlic Butter Chicken Penne fresh, store it in an airtight container in the fridge for up to 3-4 days. A simple tip is to let the pasta cool to room temperature before sealing it up to prevent moisture buildup. If you’re thinking long-term, you can freeze portions for up to 2 months. Just be sure to leave some space in the container as the pasta may expand during freezing. You can also label the containers with the date and contents for easy access later.

How to reheat without drying it out

When it’s time to enjoy those leftovers, gently reheat the pasta on the stovetop over low heat with a splash of chicken broth or cream to revive the sauce’s creaminess. This method allows for even heating while keeping the sauce rich and flavorful.

If you prefer using the microwave, do it in short intervals—about 30 seconds—stirring in between to prevent it from drying out or becoming rubbery. This ensures you savor every creamy, spicy bite just like the first time! Regularly checking on your pasta as you reheat helps maintain the perfect texture and flavor.

By following these simple storage and reheating tips, you can enjoy your Creamy Spicy Cajun Garlic Butter Chicken Penne multiple times, ensuring it remains as delightful as when it was first made.

FAQs about Creamy Spicy Cajun Garlic Butter Chicken Penne

Q1: Can I use other pasta types in this recipe?

Absolutely! While penne is perfect for this creamy sauce, feel free to use other pasta shapes like rigatoni, farfalle, or even spaghetti. Just keep in mind that cooking times may vary slightly.

Q2: Is this dish suitable for meal prep?

Yes! Creamy Spicy Cajun Garlic Butter Chicken Penne is great for meal prepping. You can make it ahead of time and store it in the fridge or freezer. Just remember to follow the storage and reheating tips for the best flavor.

Q3: How can I make this dish gluten-free?

To make this recipe gluten-free, simply substitute regular penne with a gluten-free pasta alternative. Ensure that all other ingredients, like the Cajun seasoning and chicken broth, are also gluten-free.

Q4: Can I make this dish vegetarian?

Yes, you can transform this dish into a vegetarian option by replacing the chicken with mushrooms, tempeh, or tofu. You can also amp up the vegetables by adding zucchini, bell peppers, or spinach.

Q5: What’s the best way to adjust the spice level?

The level of spice in this dish is easily adjustable. Start with a smaller amount of Cajun seasoning and gradually add more to suit your taste. For additional heat, you can include fresh jalapeños, cayenne pepper, or hot sauce.

Conclusion

Creamy Spicy Cajun Garlic Butter Chicken Penne is more than just a meal; it’s an experience that encapsulates the warmth of home kitchens and the thrill of flavor exploration. With its perfect blend of creamy sauce, tender chicken, and zesty Cajun spices, it is sure to become a beloved favorite in your household.

Whether enjoyed on a busy weeknight or during a special gathering, this dish promises satisfaction in every bite. So, gather your ingredients and let your culinary adventure begin! Enjoy cooking and savoring a plate of this delectable fusion of Italian comfort and Southern flair. Buon appetito!

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